Use of Continuous Topical Oxygen Therapy in Combination to Optimize the Chronic Wound Environment Prior to Cellular, Acellular, and Matrix-Like Product Application: A Retrospective Case Series

Wound healing should be approached in a systematic and algorithmic way, starting with wound bed optimization. This study details the use of a continuous topical oxygen therapy (cTOT) device for wound bed preparation prior to the application of cellular, acellular, and matrix-like products (CAMPs) on lower extremity wounds. Treatment consisted of 2 weeks of cTOT followed by CAMP application. In this patient cohort cTOT proved to be an effective way to improve the quality of the wound bed prior to CAMP application. With these study results, the authors believe that this combination of topical methods might have synergistic effects and improve wound healing.